| PubMed ID |
|
28008180 |
Publish Date |
|
2016 Dec |
| Journal |
|
Nat Cell Biol |
Species |
|
|
| Disease Type |
|
|
Technology |
|
|
| Title |
|
Y chromothripsis? |
| Authors |
|
Hatch EM |
| Affiliation |
|
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, Washington 98109, USA |
| Chromothripsis Definition |
|
Close-by breakpoints: NA
Copy number states: NA
Fragments random joining: NA |
| Abstract |
|
Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining. |
|
