| PubMed ID |
|
27893960 |
Publish Date |
|
2016 Nov |
| Journal |
|
Annu Rev Genet |
Species |
|
|
| Disease Type |
|
|
Technology |
|
|
| Title |
|
Eukaryotic DNA Polymerases in Homologous Recombination |
| Authors |
|
McVey M, Khodaverdian VY, Meyer D, Cerqueira PG, Heyer WD |
| Affiliation |
|
Department of Biology, Tufts University, Medford, Massachusetts 02155 |
| Chromothripsis Definition |
|
Close-by breakpoints: NA
Copy number states: NA
Fragments random joining: NA |
| Abstract |
|
Homologous recombination (HR) is a central process to ensure genomic stability in somatic cells and during meiosis. HR-associated DNA synthesis determines in large part the fidelity of the process. A number of recent studies have demonstrated that DNA synthesis during HR is conservative, less processive, and more mutagenic than replicative DNA synthesis. In this review, we describe mechanistic features of DNA synthesis during different types of HR-mediated DNA repair, including synthesis-dependent strand annealing, break-induced replication, and meiotic recombination. We highlight recent findings from diverse eukaryotic organisms, including humans, that suggest both replicative and translesion DNA polymerases are involved in HR-associated DNA synthesis. Our focus is to integrate the emerging literature about DNA polymerase involvement during HR with the unique aspects of these repair mechanisms, including mutagenesis and template switching. |
|
