| PubMed ID |
|
26091034 |
Publish Date |
|
2015 Jun |
| Journal |
|
Cell |
Species |
|
|
| Disease Type |
|
|
Technology |
|
|
| Title |
|
Linking Micronuclei to Chromosome Fragmentation. |
| Authors |
|
Hatch EM, Hetzer MW |
| Affiliation |
|
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA |
| Chromothripsis Definition |
|
Close-by breakpoints: NA
Copy number states: NA
Fragments random joining: NA |
| Abstract |
|
Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle. |
|
