| PubMed ID |
|
21215363 |
Publish Date |
|
2011 Jan |
| Journal |
|
Cell |
Species |
|
|
| Disease Type |
|
|
Technology |
|
|
| Title |
|
Cancer Genomes Evolve by Pulverizing Single Chromosomes |
| Authors |
|
Matthew Meyerson, David Pellman |
| Affiliation |
|
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 |
| Chromothripsis Definition |
|
Close-by breakpoints: NA
Copy number states: NA
Fragments random joining: NA |
| Abstract |
|
A report in this issue describes chromothripsis a new mechanism for genetic instability in cancer cells. Chromothripsis appears to be a cataclysmic event in which a single chromosome is fragmented and then reassembled. The phenomenon raises important questions of how chromosome rearrangements can be confined to defined genome segments. |
