StudyType	PubMedID	Author	Title	Journal	PublishDate	Chromosome	Disease	Technology	Species	CaseID	Platform	CNA	Connection	Gene	Affiliation	Abstract	GenomeAssembly	GEO	dbGaP	ENA	IsCancer	FusionGene
Research	28085746	Koduru PR, Wilson K, Wen J, Garcia R, Patel S, Monaghan SA	Cytogenetic and Cytogenomic Microarray Characterization of Chromothripsis in Chromosome 8 Affecting MOZ/NCOA2 (TIF2), FGFR1, RUNX1T1, and RUNX1 in a Pediatric Acute Myeloid Leukemia	J Pediatr Hematol Oncol	2017 May	8	Pediatric Acute Myeloid Leukemia	Array CGH	Homo sapiens	28085746_patient	Unknow			MOZ/NCOA2;FGFR1;RUNX1T1;RUNX1	Department of Pathology, UT Southwestern Medical Center, Dallas, TX	Concurrent perturbations in different driver genes have been reported primarily in lymphoma. In acute myeloid leukemia (AML), cases with concurrent alterations in 2 driver genes are infrequently reported. In contrast to pathogenetic pathways in lymphoma with concurrently perturbed genes, the initial gene alteration in AML arrests maturation and the alteration in the second gene promote self-renewal of the blasts. Here, we report a unique case of infantile leukemia in which chromothripsis in chromosome 8 completely altered the G-band structure and resulted in concurrent changes in MOZ/NCOA2, FGFR1, RUNX1T1, and RUNX1. These multiple-hit abnormalities in AML have not been reported previously.	GRCh37/hg19				Yes	FGFR1,RUNX1; RUNX1T1,RUNX1