StudyType	PubMedID	Author	Title	Journal	PublishDate	Chromosome	Disease	Technology	Species	CaseID	Platform	CNA	Connection	Gene	Affiliation	Abstract	GenomeAssembly	GEO	dbGaP	ENA	IsCancer	FusionGene
Research	24670920	Fernandez-Cuesta L, Peifer M, Lu X, Sun R, Ozretic L, Seidel D, Zander T, Leenders F, George J, Muller C, Dahmen I, Pinther B, Bosco G, Konrad K, Altmuller J, Nurnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soltermann A, Brustugun OT, Helland A, Solberg S, Lund-Iversen M, Ansen S, Stoelben E, Wright GM, Russell P, Wainer Z, Solomon B, Field JK, Hyde R, Davies MP, Heukamp LC, Petersen I, Perner S, Lovly CM, Cappuzzo F, Travis WD, Wolf J, Vingron M, Brambilla E, Haas SA, Buettner R, Thomas RK	Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids	Nature Communications	2014 Mar 	3,12,13	Pulmonary carcinoid	Next Generation Sequencing	Homo sapiens	S00076	Illumina HiSeq2000		hs13:39540810-39541129,hs13:98628918-98634837;hs3:158072644-158262115,hs3:71630699-71630803;hs12:109490434-109495913,hs3:14239528-14239844;hs12:300116-304493,hs3:44490051-44492076;hs3:96706171-96706835,hs12:122243069-122244011;hs12:50571665-50575822,hs12:96679820-96683000;hs12:46123831-46125097,hs3:87299023-87302616;hs3:136581127-136647070,hs3:52156413-52159199;hs12:2906302-2913091,hs3:123550392-123550519;hs3:50471768-50513632,hs3:191047373-191047513;hs13:101707771-101712320,hs3:41268694-41268843;hs12:102517663-102517819,hs3:196678758-196678907;hs12:111057640-111066662,hs12:110002923-110011184;hs3:184684462-184711853,hs13:99908581-99908773;hs3:73651503-73673326,hs3:45707139-45714272;hs13:98086751-98087039,hs12:97303528-97306595;hs13:39917770-40175529,hs3:4725988-4726891;hs12:51818672-51818821,hs13:109817246-109817341;hs12:2102428-2113491,hs3:17447909-17448018;hs3:151597637-151598493,hs3:121544895-121547378;hs3:160783186-160783320,hs3:47956305-47956395;hs3:136471036-136471179,hs3:130744346-130744440	STOML3;1IPO5;RSRC1;1FOXP1;USP30;1LSM3;SLC6A12;1ZNF445;SETD1B;IEPHA6;CDK17;1LIMA1;ARID2;ICHMP2B;POC1A;1NCK1;FKBP4;1MYLK;CACNA2D2;1CCDC50;CTNNB1;1NALCN;C12orf48;1PIGZ;TCTN1;1MMAB;GPR18;1VPS8;PDZRN3;1LIMD1;NEDD1;1RAP2A;LHFP;1ITPR1;LOC100288040;1MYO16;TBC1D5;1DCP1B;SUCNR1;1IQCB1;PPM1L;1MAP4;STAG1;IASTE1;	Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50924 Cologne, Germany	Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and observe frequent mutations in chromatin-remodelling genes. Covalent histone modifiers and subunits of the SWI/SNF complex are mutated in 40 and 22.2% of the cases, respectively, with MEN1, PSIP1 and ARID1A being recurrently affected. In contrast to small-cell lung cancer and large-cell neuroendocrine lung tumours, TP53 and RB1 mutations are rare events, suggesting that pulmonary carcinoids are not early progenitor lesions of the highly aggressive lung neuroendocrine tumours but arise through independent cellular mechanisms. These data also suggest that inactivation of chromatin-remodelling genes is sufficient to drive transformation in pulmonary carcinoids. 	GRCh37/hg19				Yes	ARID2,ICHMP2B;C12orf48,1PIGZ;CACNA2D2,1CCDC50;CDK17,1LIMA1;CTNNB1,1NALCN;FKBP4,1MYLK;GPR18,1VPS8;LHFP,1ITPR1;LOC100288040,1MYO16;NEDD1,1RAP2A;PDZRN3,1LIMD1;POC1A,1NCK1;PPM1L,1MAP4;RSRC1,1FOXP1;SETD1B,IEPHA6;SLC6A12,1ZNF445;STAG1,IASTE1;STOML3,1IPO5;SUCNR1,1IQCB1;TBC1D5,1DCP1B;TCTN1,1MMAB;USP30,1LSM3