StudyType	PubMedID	Author	Title	Journal	PublishDate	Chromosome	Disease	Technology	Species	CaseID	Platform	CNA	Connection	Gene	Affiliation	Abstract	GenomeAssembly	GEO	dbGaP	ENA	IsCancer	FusionGene
Research	23930239	Jianming Pei, Suresh C. Jhanwar, Joseph R. Testa	Chromothripsis in a case of TP53-deficient chronic lymphocytic leukemia	Leukemia Research Reports	2012 Nov	2,5,6,7	Chronic lymphocytic leukemia	SNP Array	Homo sapiens	23930239_1	Affymetrix CytoScan HD array			TP53;IGH	Cancer Biology Program and Clinical Cytogenomics Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA	We describe genomic findings in a case of CLL with del(17p13.1) by FISH, in which SNP array analysis revealed chromothripsis, a phenomenon by which regions of the cancer genome are shattered and recombined to generate frequent oscillations between two DNA copy number states.The findings illustrate the value of SNP arrays for precise whole genome profiling in CLL and for the detection of alterations that would be overlooked with a standard FISH panel. This second report of chromothripsis in CLL indicates that this phenomenon is a recurrent change in this disease.					Yes	NA