StudyType	PubMedID	Author	Title	Journal	PublishDate	Chromosome	Disease	Technology	Species	CaseID	Platform	CNA	Connection	Gene	Affiliation	Abstract	GenomeAssembly	GEO	dbGaP	ENA	IsCancer	FusionGene
Research	22265402	Rausch T, Jones DT, Zapatka M, Stutz AM, Zichner T, Weischenfeldt J, Jager N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Bl	Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations	Cell	2012 Jan	3,4,14	Sonic-Hedgehog medulloblastoma	Next Generation Sequencing	Homo sapiens	LFS-MB1	Illumina HiSeq 2000	chr1:63444401-63528602:-1;chr3:113498368-130583576:-1;chr4:124191414-164362015:-1;chr4:164458233-175842161:-1;chr8:3492450-3852149:-1;chr12:11191764-11292955:-1;chr12:33535367-33818924:-1;chr14:106815470-107130874:-1;chr4:124098068-124191394:1;chr4:159597606-159858310:1;chr4:164362032-164458144:1;chr4:170360650-170395000:1;chr4:171723347-171841028:1;chr4:175842203-176109339:1;chr14:20664952-20670397:1;chr14:22803240-22833959:1;chr14:79925792-80106000:1;chr14:80115001-80144983:1;chr14:80230194-80311870:1;chr2:14216912-16903663:1;chr3:112938115-113498342:1;chr3:130583569-131022000:1;chr3:139617001-141173250:1	hs4:159858310-159858310,hs14:79925792-79925792;hs4:170360650-170360650,hs14:22803240-22803240;hs4:176109339-176109339,hs14:80230194-80230194;hs4:171723347-171723347,hs14:20670397-20670397;hs11:38226283-38226283,hs17:16021393-16021393;hs13:50502098-50502098,hs18:70220182-70220182;hs1:179666590-179666590,hs1:182191375-182191375;hs2:14216833-14216833,hs2:16903720-16903720;hs2:115961657-115961657,hs2:120963994-120963994;hs2:116503651-116503651,hs2:207025403-207025403;hs2:120596559-120596559,hs2:122113238-122113238;hs2:120610969-120610969,hs2:183771998-183771998;hs2:121087792-121087792,hs2:121835816-121835816;hs2:183737296-183737296,hs2:200282232-200282232;hs3:112938044-112938044,hs3:141173305-141173305;hs3:131021629-131021629,hs3:139858259-139858259;hs3:139616963-139616963,hs3:139858020-139858020;hs4:116681164-116681164,hs4:127291493-127291493;hs4:116953341-116953341,hs4:164151091-164151091;hs4:124098007-124098007,hs4:170394907-170394907;hs4:124543475-124543475,hs4:164588491-164588491;hs4:128368058-128368058,hs4:170025020-170025020;hs4:159597587-159597587,hs4:171841070-171841070;hs4:164803329-164803329,hs4:170426855-170426855;hs7:64763921-64763921,hs7:66469133-66469133;hs10:13089870-13089870,hs10:50289722-50289722;hs10:29054168-29054168,hs10:62557463-62557463;hs10:48429595-48429595,hs10:49919974-49919974;hs11:38614205-38614205,hs11:38855827-38855827;hs11:38615134-38615134,hs11:41317169-41317169;hs11:41577279-41577279,hs11:43868468-43868468;hs14:20664900-20664900,hs14:80311910-80311910;hs16:21667732-21667732,hs16:24069189-24069189;hs22:21317195-21317195,hs22:21398564-21398564;hsX:49210465-49210465,hsX:49366877-49366877	ADAM29;ANAPC10;BOC;FBXW7;GAB1;GLI2;GRIA2;GYPA;GYPB;IL15;MYCN;NEK11;PPP2R2C;TRIM2;WDR17	European Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg, Germany	Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering massive, complex chromosome rearrangements. Integrating TP53 status with microarray and deep sequencing-based DNA rearrangement data in additional patients reveals a striking association between TP53 mutation and chromothripsis in SHH-MBs. Analysis of additional tumor entities substantiates a link between TP53 mutation and chromothripsis, and indicates a context-specific role for p53 in catastrophic DNA rearrangements. Among these, we observed a strong association between somatic TP53 mutations and chromothripsis in acute myeloid leukemia. These findings connect p53 status and chromothripsis in specific tumor types, providing a genetic basis for understanding particularly aggressive subtypes of cancer.	GRCh37/hg19	GSE14437;GSE32462;GSE19101;GSE23452;GSE34323;GSE34258		EGAS00001000085	Yes	NA
Research	22265402	Rausch T, Jones DT, Zapatka M, Stutz AM, Zichner T, Weischenfeldt J, Jager N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Bl	Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations	Cell	2012 Jan	3,8,17,X	Sonic-Hedgehog medulloblastoma	Next Generation Sequencing	Homo sapiens	LFS-MB2	Illumina HiSeq 2000	chr4:188409906-189503084:-1;chr5:5922885-14314337:-1;chr5:50792381-98447862:-1;chr6:29911431-30228533:-1;chr7:90522308-90588071:-1;chr7:90612330-92469025:-1;chr7:91376469-92127901:-1;chr8:1875838-10722429:-1;chr8:9629722-17109168:-1;chr11:23172601-24575386:-1;chr17:48871254-48940606:-1;chr18:45077868-56806980:-1;chr19:13623874-15447939:-1;chr19:16494334-16994600:-1;chrX:117637014-120303308:-1;chrX:121432913-130860060:-1	hs2:50943844-50943844,hs2:51065148-51065148;hs3:4984736-4984736,hs3:36349735-36349735;hs4:189232547-189232547,hs4:189534830-189534830;hs5:1410207-1410207,hs5:103772276-103772276;hs5:5889265-5889265,hs5:14348517-14348517;hs5:54107033-54107033,hs5:96117539-96117539;hs5:56540227-56540227,hs5:103054335-103054335;hs5:99317512-99317512,hs5:104095025-104095025;hs7:90471247-90471247,hs7:105787298-105787298;hs7:90560959-90560959,hs7:106086607-106086607;hs7:90640706-90640706,hs7:90768468-90768468;hs7:90715844-90715844,hs7:91497552-91497552;hs7:90724457-90724457,hs7:106482610-106482610;hs7:90998372-90998372,hs7:105987011-105987011;hs7:91026730-91026730,hs7:92130470-92130470;hs7:91560973-91560973,hs7:106105823-106105823;hs7:91663486-91663486,hs7:92128327-92128327;hs7:91778926-91778926,hs7:92229681-92229681;hs7:91791410-91791410,hs7:92473297-92473297;hs7:91803566-91803566,hs7:92030918-92030918;hs7:92351343-92351343,hs7:105896877-105896877;hs7:92381639-92381639,hs7:92557144-92557144;hs7:92845067-92845067,hs7:106761774-106761774;hs7:129677752-129677752,hs7:132312507-132312507;hs8:9650762-9650762,hs8:15733400-15733400;hs8:9695585-9695585,hs8:16544505-16544505;hs8:10501739-10501739,hs8:66488505-66488505;hs8:16553290-16553290,hs8:48957757-48957757;hs8:17075594-17075594,hs8:66502400-66502400;hs8:28076906-28076906,hs8:66479399-66479399;hs8:42678552-42678552,hs8:75717941-75717941;hs8:48957507-48957507,hs8:68047639-68047639;hs17:15853987-15853987,hs17:54957986-54957986;hs17:26743059-26743059,hs17:27067877-27067877;hs17:27079023-27079023,hs17:55022936-55022936;hs17:31921782-31921782,hs17:43403969-43403969;hs17:32772969-32772969,hs17:32879681-32879681;hs17:50402026-50402026,hs17:55210345-55210345;hs17:55164797-55164797,hs17:64399654-64399654;hs17:57571985-57571985,hs17:58356131-58356131;hs18:40529221-40529221,hs18:44778253-44778253;hs18:40723689-40723689,hs18:43436945-43436945;hs18:40845756-40845756,hs18:41443431-41443431;hs18:41968741-41968741,hs18:42887677-42887677;hs18:42896239-42896239,hs18:44486476-44486476;hs18:43443538-43443538,hs18:44140503-44140503;hs19:53362609-53362609,hs19:53969645-53969645;hsX:2833855-2833855,hsX:78605776-78605776;hsX:65918786-65918786,hsX:136944645-136944645;hsX:71079504-71079504,hsX:91194619-91194619;hsX:73782637-73782637,hsX:87033199-87033199;hsX:73825461-73825461,hsX:73890151-73890151;hsX:73833598-73833598,hsX:106515760-106515760;hsX:87062791-87062791,hsX:127534168-127534168;hsX:91212287-91212287,hsX:92107029-92107029;hsX:92000657-92000657,hsX:127505080-127505080;hsX:93878280-93878280,hsX:119920717-119920717;hsX:120424739-120424739,hsX:149004603-149004603;hsX:121407933-121407933,hsX:133389821-133389821;hs3:3865919-3865919,hsX:121844920-121844920;hs12:34841679-34841679,hs8:46872792-46872792;hs12:34841679-34841679,hs19:27752864-27752864;hs20:26318595-26318595,hs5:46346297-46346297;hs20:26318603-26318603,hsX:130893215-130893215;hsX:106556626-106556626,hs3:3588416-3588416;hsX:121804642-121804642,hs12:32269547-32269547;hsX:121947652-121947652,hs3:36334979-36334979;hsX:133358177-133358177,hs3:4932716-4932716	CDK6;DCX;DDX3X;GLI2;FOXO4;MAGEA1;MYCN;NAMPT;TAF1	European Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg, Germany	Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering massive, complex chromosome rearrangements. Integrating TP53 status with microarray and deep sequencing-based DNA rearrangement data in additional patients reveals a striking association between TP53 mutation and chromothripsis in SHH-MBs. Analysis of additional tumor entities substantiates a link between TP53 mutation and chromothripsis, and indicates a context-specific role for p53 in catastrophic DNA rearrangements. Among these, we observed a strong association between somatic TP53 mutations and chromothripsis in acute myeloid leukemia. These findings connect p53 status and chromothripsis in specific tumor types, providing a genetic basis for understanding particularly aggressive subtypes of cancer.	GRCh37/hg19	GSE14437;GSE32462;GSE19101;GSE23452;GSE34323;GSE34258		EGAS00001000085	Yes	NAMPT,CDK6
Research	22265402	Rausch T, Jones DT, Zapatka M, Stutz AM, Zichner T, Weischenfeldt J, Jager N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Bl	Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations	Cell	2012 Jan	3,15	Sonic-Hedgehog medulloblastoma	Next Generation Sequencing	Homo sapiens	LFS-MB3	Illumina HiSeq 2000	chr1:81896744-82117509:-1;chr1:145079866-145189859:-1;chr2:110109313-110251287:-1;chr2:149690639-149790578:-1;chr2:233210308-233318177:-1;chr3:129535039-142240426:-1;chr4:867271-1581792:-1;chr4:18285761-96336487:-1;chr4:18414602-28991025:-1;chr4:134478891-166432306:-1;chr5:180375000-180432033:-1;chr6:152778995-152955408:-1;chr7:2153486-15038940:-1;chr7:56564619-57477969:-1;chr8:35121733-35291026:-1;chr12:17722945-30145481:-1;chr13:114325887-114426023:-1;chr15:25626015-35404817:-1;chr15:27592310-88731192:-1;chr15:27592381-50831447:-1;chr15:27638165-65034324:-1;chr15:27692334-35404806:-1;chr15:27692341-34751965:-1;chr15:28025119-29058591:-1;chr15:29564215-31973108:-1;chr15:34028982-84374758:-1;chr15:34602258-66226936:-1;chr15:34752392-35404837:-1;chr15:35405071-47542305:-1;chr15:35405083-60559493:-1;chr15:35405921-89774781:-1;chr15:35405943-56590661:-1;chr15:35406062-47784193:-1;chr15:35406068-61425482:-1;chr15:36048000-38826328:-1;chr15:36079877-62499897:-1;chr15:36141398-77852311:-1;chr15:38019644-85778959:-1;chr15:38354283-38856739:-1;chr15:38963868-55081326:-1;chr15:41476300-54247872:-1;chr15:41612473-84028139:-1;chr15:43080211-81247110:-1;chr15:44785584-82339510:-1;chr15:45265673-51715441:-1;chr15:45497532-67049070:-1;chr15:47535310-96255463:-1;chr15:47676606-92567896:-1;chr15:47845948-55080236:-1;chr15:49628274-59475290:-1;chr15:50108383-87670940:-1;chr15:50798716-101663200:-1;chr15:50813733-66438292:-1;chr15:50824388-63715435:-1;chr15:50833651-88731133:-1;chr15:56406665-100282989:-1;chr15:56614544-62885408:-1;chr15:57103408-58691682:-1;chr15:58386821-84945701:-1;chr15:60122494-88782529:-1;chr15:62784551-69024995:-1;chr15:64448240-87886231:-1;chr15:65433008-101841362:-1;chr15:66242159-93836383:-1;chr15:66836685-86095274:-1;chr15:70301222-92712797:-1;chr15:73600835-100160977:-1;chr15:75498764-76064634:-1;chr15:89416605-91127851:-1;chr18:75721727-75772072:-1;chr21:41468328-44066701:-1;chr21:42955522-43005639:-1;chrY:14440191-15234430:-1;chr15:37593001-37809000:1;chr15:44509001-44786000:1;chr15:46078001-47139000:1;chr15:54279001-54476000:1;chr15:65861001-65933000:1;chr15:66497001-66691000:1;chr15:77636001-77848000:1;chr15:79825001-79979000:1;chr15:82339001-83057580:1;chr15:85315001-85611000:1;chr15:99055001-100149000:1;chr2:13598001-17621000:1	hs1:78170570-78170570,hs1:79568682-79568682;hs1:78990540-78990540,hs1:83363860-83363860;hs2:13598087-13598087,hs2:17620755-17620755;hs2:170355427-170355427,hs2:170478847-170478847;hs3:53898723-53898723,hs3:53981596-53981596;hs4:1600174-1600174,hs4:21569204-21569204;hs4:1648566-1648566,hs4:1772823-1772823;hs4:1759629-1759629,hs4:2041362-2041362;hs4:18415910-18415910,hs4:31101146-31101146;hs4:19044222-19044222,hs4:23704174-23704174;hs4:21765873-21765873,hs4:23062496-23062496;hs4:21807855-21807855,hs4:22714648-22714648;hs4:22617210-22617210,hs4:22715322-22715322;hs4:24718977-24718977,hs4:25400304-25400304;hs4:24732441-24732441,hs4:30095895-30095895;hs4:101974096-101974096,hs4:139906781-139906781;hs5:176195896-176195896,hs5:176406025-176406025;hs6:64338556-64338556,hs6:105479874-105479874;hs6:157609433-157609433,hs6:157691407-157691407;hs7:1146265-1146265,hs7:8133233-8133233;hs7:1149649-1149649,hs7:7800358-7800358;hs7:6529998-6529998,hs7:18228910-18228910;hs7:15171873-15171873,hs7:26191860-26191860;hs7:61056588-61056588,hs7:61675249-61675249;hs9:84926330-84926330,hs9:85100582-85100582;hs9:99381288-99381288,hs9:99638918-99638918;hs9:112209390-112209390,hs9:112344043-112344043;hs12:2387147-2387147,hs12:6705540-6705540;hs15:23291122-23291122,hs15:33806523-33806523;hs15:24850022-24850022,hs15:39119625-39119625;hs15:25312632-25312632,hs15:96150563-96150563;hs15:25625740-25625740,hs15:35406091-35406091;hs15:25990006-25990006,hs15:68635056-68635056;hs15:26026945-26026945,hs15:33183012-33183012;hs15:26031340-26031340,hs15:78474256-78474256;hs15:26129574-26129574,hs15:39873798-39873798;hs15:26683575-26683575,hs15:68950551-68950551;hs15:26941413-26941413,hs15:73072495-73072495;hs15:27176088-27176088,hs15:73397401-73397401;hs15:27475815-27475815,hs15:40752573-40752573;hs15:27692074-27692074,hs15:35406067-35406067;hs15:27692092-27692092,hs15:35404831-35404831;hs15:27692336-27692336,hs15:35406053-35406053;hs15:27829421-27829421,hs15:79452789-79452789;hs15:27910654-27910654,hs15:35427659-35427659;hs15:27911295-27911295,hs15:35405121-35405121;hs15:27987635-27987635,hs15:51025797-51025797;hs15:28262125-28262125,hs15:66438978-66438978;hs15:29363291-29363291,hs15:34721143-34721143;hs15:29932964-29932964,hs15:60131426-60131426;hs15:30357629-30357629,hs15:54269262-54269262;hs15:30935070-30935070,hs15:67256394-67256394;hs15:32195355-32195355,hs15:48516453-48516453;hs15:33145274-33145274,hs15:60373138-60373138;hs15:33153560-33153560,hs15:45617574-45617574;hs15:33814655-33814655,hs15:60454777-60454777;hs15:33840954-33840954,hs15:95576509-95576509;hs15:33987983-33987983,hs15:36878965-36878965;hs15:34082813-34082813,hs15:90796798-90796798;hs15:34154892-34154892,hs15:73178927-73178927;hs15:3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Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg, Germany	Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering massive, complex chromosome rearrangements. Integrating TP53 status with microarray and deep sequencing-based DNA rearrangement data in additional patients reveals a striking association between TP53 mutation and chromothripsis in SHH-MBs. Analysis of additional tumor entities substantiates a link between TP53 mutation and chromothripsis, and indicates a context-specific role for p53 in catastrophic DNA rearrangements. Among these, we observed a strong association between somatic TP53 mutations and chromothripsis in acute myeloid leukemia. These findings connect p53 status and chromothripsis in specific tumor types, providing a genetic basis for understanding particularly aggressive subtypes of cancer.	GRCh37/hg19	GSE14437;GSE32462;GSE19101;GSE23452;GSE34323;GSE34258		EGAS00001000085	Yes	NA
Research	22265402	Rausch T, Jones DT, Zapatka M, Stutz AM, Zichner T, Weischenfeldt J, Jager N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Bl	Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations	Cell	2012 Jan	2,12	Sonic-Hedgehog medulloblastoma	Next Generation Sequencing	Homo sapiens	LFS-MB4	Illumina HiSeq 2000	chr2:2074250-15913826:-1;chr2:14156532-91794235:-1;chr2:23727492-121124467:-1;chr2:110109209-110251278:-1;chr2:149690550-149790676:-1;chr4:2071045-33527520:-1;chr4:7250202-7366570:-1;chr4:53097786-54003362:-1;chr4:55196757-55277010:-1;chr4:56788702-57032247:-1;chr4:103168108-107714052:-1;chr5:155138565-155188667:-1;chr5:180374717-180432585:-1;chr11:69089751-69139794:-1;chr12:4512391-23390634:-1;chr12:7540228-32371383:-1;chr12:19854988-20369213:-1;chr13:114325864-114426002:-1;chr15:34034045-47295315:-1;chr18:75721852-75772156:-1;chr21:42955390-43005560:-1;chr2:1934384-2074250:1;chr2:15913826-16157942:1;chr2:23554909-23727492:1;chr2:48236089-48566218:1;chr2:56279625-56326244:1;chr2:114704001-115892335:1;chr2:119939305-120031183:1;chr2:121124467-121431476:1;chr2:121432593-123704028:1;chr2:152495756-152743190:1	hs1:91853138-91853138,hs11:85195217-85195217;hs1:91853163-91853163,hs17:33478114-33478114;hs1:156186643-156186643,hs21:9826979-9826979;hs1:156186648-156186648,hs2:133013270-133013270;hs1:156186652-156186652,hs16:33963032-33963032;hs17:33478369-33478369,hs21:9827543-9827543;hs20:29653973-29653973,hs9:68425913-68425913;hs21:9827569-9827569,hs11:85195007-85195007;hs2:1934384-1934384,hs2:120031183-120031183;hs2:16157942-16157942,hs2:48566218-48566218;hs2:23554909-23554909,hs2:48236089-48236089;hs2:56279625-56279625,hs2:123704028-123704028;hs2:56326244-56326244,hs2:152743190-152743190;hs2:85364248-85364248,hs2:88644722-88644722;hs2:114704412-114704412,hs2:152495756-152495756;hs2:115892335-115892335,hs2:121431476-121431476;hs2:119939305-119939305,hs2:121432593-121432593;hs4:38623762-38623762,hs4:41458623-41458623;hs4:56803911-56803911,hs4:56872432-56872432;hs6:157609435-157609435,hs6:157691649-157691649;hs12:2356776-2356776,hs12:2884168-2884168;hs12:2356986-2356986,hs12:2884265-2884265;hs12:3596541-3596541,hs12:21013620-21013620;hs12:3597143-3597143,hs12:21013616-21013616;hs12:4512436-4512436,hs12:19959311-19959311;hs12:5303246-5303246,hs12:22259157-22259157;hs12:11188586-11188586,hs12:29102643-29102643;hs12:19919957-19919957,hs12:20409715-20409715;hs12:19956957-19956957,hs12:20345242-20345242;hs12:19958257-19958257,hs12:23390562-23390562;hs12:20356483-20356483,hs12:23525091-23525091;hs12:20359046-20359046,hs12:23523379-23523379;hs12:20359221-20359221,hs12:23525579-23525579;hs12:20451650-20451650,hs12:22761890-22761890;hs12:22248606-22248606,hs12:22478408-22478408;hs12:22482795-22482795,hs12:23315033-23315033;hs12:23184210-23184210,hs12:23354948-23354948;hs12:23184480-23184480,hs12:23355160-23355160;hs12:31864190-31864190,hs12:32478301-32478301;hs14:26854924-26854924,hs14:30667922-30667922;hs17:41399870-41399870,hs17:41466036-41466036	ALK;FSHR;GIGYF2;GLI2;ITGAV;MSH2;MYCN;NDUFA10;NEB;TMSB10	European Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg, Germany	Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering massive, complex chromosome rearrangements. Integrating TP53 status with microarray and deep sequencing-based DNA rearrangement data in additional patients reveals a striking association between TP53 mutation and chromothripsis in SHH-MBs. Analysis of additional tumor entities substantiates a link between TP53 mutation and chromothripsis, and indicates a context-specific role for p53 in catastrophic DNA rearrangements. Among these, we observed a strong association between somatic TP53 mutations and chromothripsis in acute myeloid leukemia. These findings connect p53 status and chromothripsis in specific tumor types, providing a genetic basis for understanding particularly aggressive subtypes of cancer.	GRCh37/hg19	GSE14437;GSE32462;GSE19101;GSE23452;GSE34323;GSE34258		EGAS00001000085	Yes	ACTR3,NEB