StudyType	PubMedID	Author	Title	Journal	PublishDate	Chromosome	Disease	Technology	Species	CaseID	Platform	CNA	Connection	Gene	Affiliation	Abstract	GenomeAssembly	GEO	dbGaP	ENA	IsCancer	FusionGene
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	1,4,12,13,15	Chronic lymphocytic leukemia	Next Generation Sequencing	Homo sapiens	PD3172a	Illumina Genome Analyzer II		hs1:170758115-170758115,hs4:173998000-173998000;hs1:170822660-170822660,hs4:119852135-119852135;hs1:172107770-172107770,hs4:81649760-81649760;hs4:70257618-70257618,hs4:105957165-105957165;hs4:70261129-70261129,hs4:80291486-80291486;hs4:71223258-71223258,hs4:81652006-81652006;hs4:77014716-77014716,hs4:170643878-170643878;hs4:77030145-77030145,hs4:119951745-119951745;hs4:77030147-77030147,hs4:119849842-119849842;hs4:77037605-77037605,hs4:80293316-80293316;hs4:77040817-77040817,hs4:81648619-81648619;hs4:77040842-77040842,hs4:86837950-86837950;hs4:77042952-77042952,hs4:105696487-105696487;hs4:78650104-78650104,hs4:169386977-169386977;hs4:78651579-78651579,hs4:81649652-81649652;hs4:80226572-80226572,hs4:170624360-170624360;hs4:80226595-80226595,hs4:81313713-81313713;hs4:80287286-80287286,hs4:170642768-170642768;hs4:80291307-80291307,hs4:107243297-107243297;hs4:80467681-80467681,hs4:119852103-119852103;hs4:80506413-80506413,hs4:104234697-104234697;hs4:81648711-81648711,hs4:99640521-99640521;hs4:99639025-99639025,hs4:107217807-107217807;hs4:104243155-104243155,hs4:167629140-167629140;hs4:105652371-105652371,hs4:105957018-105957018;hs4:105652481-105652481,hs4:105967833-105967833;hs4:105662342-105662342,hs4:106201407-106201407;hs4:105700611-105700611,hs12:59712049-59712049;hs4:105739492-105739492,hs4:119952131-119952131;hs4:106197097-106197097,hs4:107243349-107243349;hs4:107216936-107216936,hs4:170645224-170645224;hs4:119501206-119501206,hs4:169381508-169381508;hs4:119956158-119956158,hs4:167620640-167620640;hs4:162402650-162402650,hs12:59468319-59468319;hs4:167620542-167620542,hs15:21792673-21792673;hs4:169386926-169386926,hs4:170642728-170642728;hs4:170624368-170624368,hs4:173997876-173997876;hs4:173959368-173959368,hs12:59539267-59539267;hs12:59707038-59707038,hs15:23138396-23138396;hs13:49474759-49474759,hs13:50488499-50488499;hs15:21280398-21280398,hs15:40811223-40811223;hs4:104234642-104234942,hs4:107217311-107217611;hs4:106199979-106200279,hs4:107220534-107220834;hs4:106201375-106201675,hs15:21786025-21786325;hs4:80506144-80506444,hs15:21280101-21280401	TBCK_HUMAN;NEK1;ZBTB37;C4orf22	Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	ZBTB37,C4orf22;TBCK_HUMAN,NEK1
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	4,9,13	Chronic lymphocytic leukemia	Next Generation Sequencing	Homo sapiens	PD3175a	Illumina Genome Analyzer II		hs4:99985365-99985365,hs10:102805821-102805821;hs4:169615303-169615303,hs9:21789308-21789308;hs4:169770605-169770605,hs9:21457739-21457739;hs4:99990414-99990714,hs9:21464986-21465286;hs9:20322528-20322528,hs13:47760651-47760651;hs9:21465000-21465000,hs13:47765821-47765821;hs9:22237156-22237156,hs13:50426343-50426343;hs11:79215247-79215247,hs11:126343811-126343811;hs13:47298401-47298401,hs13:50430220-50430220	CDKN2A;miR-15a/16-1	Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	NA
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	5	Renal cancer	Next Generation Sequencing	Homo sapiens	TK10	Illumina Genome Analyzer II		hs5:1391571-1391571,hs5:58882426-58882426;hs5:5997677-5997677,hs5:172885499-172885499;hs5:82591088-82591088,hs5:87333255-87333255;hs5:150892726-150892726,hs5:179506251-179506251;hs5:116036409-116036709,hs5:121979782-121980082;hs5:40837990-40837990,hs5:155087856-155087856;hs5:122724312-122724312,hs5:149292657-149292657;hs5:80245290-80245290,hs5:88043252-88043252;hs5:30903628-30903628,hs5:179575729-179575729;hs5:176692704-176693004,hs5:176849251-176849551;hs5:14835731-14836031,hs5:154507851-154508151;hs5:155231047-155231047,hs5:155239167-155239167;hs5:10681875-10681875,hs5:115348662-115348662;hs5:93783789-93783789,hs5:118735125-118735125;hs5:8009373-8009673,hs5:158710597-158710897;hs5:58427832-58427832,hs5:81386796-81386796;hs5:16203070-16203070,hs5:171178291-171178291;hs5:156463031-156463031,hs5:167283727-167283727;hs5:167251737-167251737,hs5:167283889-167283889;hs5:116036273-116036273,hs5:125175837-125175837;hs5:143377847-143377847,hs5:170778628-170778628;hs5:149360242-149360242,hs5:159241778-159241778;hs5:40069776-40069776,hs5:167246377-167246377;hs5:65989166-65989466,hs5:150893224-150893524;hs5:1391961-1391961,hs5:40252955-40252955;hs5:170777227-170777527,hs5:171176733-171177033;hs5:17269304-17269304,hs5:130533138-130533138;hs5:25833862-25833862,hs5:41970498-41970498;hs5:164531274-164531274,hs5:170030775-170030775;hs5:85333134-85333134,hs5:93781890-93781890;hs5:20868092-20868092,hs5:34407621-34407621;hs5:82594065-82594065,hs5:93387598-93387598;hs5:115347784-115347784,hs5:116728213-116728213;hs5:10639936-10639936,hs5:81385621-81385621;hs5:116145701-116145701,hs5:124097158-124097158;hs5:116728965-116729265,hs5:164535526-164535826;hs5:114877024-114877024,hs5:114913231-114913231;hs5:118734017-118734017,hs5:143377782-143377782;hs5:142741896-142741896,hs5:172986135-172986135;hs5:102946493-102946493,hs5:110916800-110916800;hs5:4254208-4254208,hs5:85333005-85333005;hs5:146248274-146248274,hs5:149293070-149293070;hs5:73700457-73700457,hs5:95495199-95495199;hs5:110989909-110989909,hs5:171901209-171901209;hs5:110918352-110918352,hs5:154476395-154476395;hs5:87574938-87574938,hs5:119641592-119641592;hs5:4253813-4253813,hs5:8009710-8009710;hs5:13558101-13558101,hs5:24794276-24794276;hs5:10705318-10705318,hs5:149360688-149360688;hs5:84038311-84038311,hs5:96658107-96658107;hs5:32281581-32281581,hs5:66102085-66102085;hs5:93386712-93386712,hs5:124097383-124097383;hs5:14231532-14231532,hs5:129092795-129092795;hs5:41971777-41971777,hs5:157749099-157749099;hs5:148091942-148091942,hs5:154506363-154506363	LMAN2;C5orf21;CCDC100;PDLIM7;ZNF608;PDE6A	Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	C5orf21,ZNF608;CCDC100,PDE6A;LMAN2,PDLIM7
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	3,4,7,8,9	Chordoma	Next Generation Sequencing	Homo sapiens	PD3808a	Illumina Genome Analyzer II		hs16:69265309-69265309,hs21:36237341-36237341;hs4:123124159-123124159,hs4:155159776-155159776;hs4:160244766-160244766,hs9:12975640-12975640;hs3:139340487-139340487,hs3:188568303-188568303;hs3:105009813-105009813,hs3:115981971-115981971;hs3:125751870-125751870,hs3:125997366-125997366;hs9:12406646-12406646,hs9:13055939-13055939;hs3:128893222-128893222,hs3:193227946-193227946;hs7:114409936-114409936,hs9:7316206-7316206;hs7:153836592-153836592,hs8:15649993-15649993;hs7:153199562-153199562,hs8:35945668-35945668;hs3:111440555-111440555,hs9:12598203-12598203;hs3:198269534-198269534,hs8:20151294-20151294;hs7:142008035-142008035,hs7:142194692-142194692;hs7:153541205-153541205,hs8:37921420-37921420;hs8:36069934-36069934,hs8:37943155-37943155;hs3:107391861-107391861,hs3:154927561-154927561;hs3:107458456-107458456,hs4:155589198-155589198;hs8:23182631-23182631,hs9:18177075-18177075;hs7:118260884-118260884,hs8:23089086-23089086;hs3:103437636-103437636,hs3:111344479-111344479;hs7:114353063-114353063,hs8:6297119-6297119;hs3:112126377-112126377,hs3:176209249-176209249;hs7:124797117-124797117,hs8:24255233-24255233;hs9:14680733-14680733,hs9:15703851-15703851;hs4:143617033-143617033,hs4:154386445-154386445;hs3:175287849-175287849,hs7:125094174-125094174;hs21:31753291-31753291,hs21:32980788-32980788;hs8:3380667-3380667,hs9:2183009-2183009;hs3:169305809-169305809,hs4:159579170-159579170;hs3:143632931-143632931,hs7:115987536-115987536;hs3:131029503-131029503,hs8:27510652-27510652;hs7:108221716-108221716,hs7:111876430-111876430;hs8:2259557-2259557,hs9:5099157-5099157;hs4:155125184-155125184,hs4:155164041-155164041;hs3:185109118-185109118,hs8:22917884-22917884;hs3:109188323-109188323,hs8:13206097-13206097;hs3:104112605-104112605,hs8:31816236-31816236;hs3:173006812-173006812,hs3:179412453-179412453;hs4:154567973-154568273,hs8:20975643-20975943;hs3:139342416-139342716,hs8:22732250-22732550;hs7:108220627-108220927,hs8:40732209-40732509;hs3:169230059-169230359,hs7:114812766-114813066;hs3:188647808-188648108,hs4:147925705-147926005;hs7:111428079-111428379,hs7:114488081-114488381;hs4:155825482-155825782,hs8:31903051-31903351;hs3:125730301-125730301,hs3:125985653-125985653;hs3:104685671-104685971,hs4:157499321-157499621;hs7:124355725-124356025,hs9:13630760-13631060;hs3:125262369-125262369,hs3:157388224-157388224;hs3:129206188-129206488,hs3:148104334-148104634;hs3:185809534-185809834,hs9:3851333-3851633;hs3:127741362-127741662,hs7:150238171-150238471;hs7:117939595-117939895,hs9:18090627-18090927;hs4:156554532-156554532,hs8:40025625-40025625;hs4:147352460-147352460,hs7:153709547-153709547;hs3:127952177-127952177,hs9:9227307-9227307;hs3:46413547-46413547,hs19:46781534-46781534;hs3:194586374-194586374,hs8:3671798-3671798;hs3:162491470-162491470,hs7:121614819-121614819;hs3:166314683-166314683,hs7:107455505-107455505;hs3:130680026-130680026,hs3:150022346-150022346;hs3:150022492-150022492,hs9:14521843-14521843;hs3:46414148-46414148,hs22:18459484-18459484;hs3:164420972-164420972,hs3:164591947-164591947;hs7:105982090-105982090,hs7:124219623-124219623;hs21:33477317-33477317,hs21:35741213-35741213;hs8:15518658-15518658,hs9:24805672-24805672;hs7:123687423-123687423,hs9:7745598-7745598;hs4:157378862-157378862,hs8:29283626-29283626;hs3:138664031-138664031,hs8:24040020-24040020;hs3:158987767-158987767,hs3:191886018-191886018;hs3:108235308-108235308,hs8:35956663-35956663;hs3:168438541-168438541,hs7:118533955-118533955;hs4:155594968-155594968,hs8:28111767-28111767;hs7:108225342-108225342,hs7:112844222-112844222;hs3:144533104-144533104,hs8:37921782-37921782;hs3:164360375-164360375,hs3:190445467-190445467;hs7:122617539-122617539,hs7:123024103-123024103;hs7:103750502-103750502,hs8:38708000-38708000;hs3:97874051-97874051,hs7:112292247-112292247;hs20:52206438-52206438,hs20:52208530-52208530;hs3:141643303-141643303,hs3:180957055-180957055;hs3:129207203-129207203,hs3:156247362-156247362;hs3:11862467-11862467,hs20:2071667-2071667;hs3:149087043-149087043,hs8:39311333-39311333;hs8:19904290-19904590,hs9:20235876-20236176;hs4:155970697-155970697,hs4:156555443-156555443;hs3:118147498-118147498,hs8:36363040-36363040;hs4:156544080-156544080,hs9:12947309-12947309;hs3:102910471-102910471,hs7:124918640-124918640;hs3:144477589-144477589,hs9:1779626-1779626;hs8:20056378-20056378,hs8:39016067-39016067;hs3:149088054-149088354,hs7:117440947-117441247;hs8:15503001-15503301,hs8:39740184-39740484;hs3:103438814-103439114,hs9:19858660-19858960;hs3:116916724-116917024,hs9:25264982-25265282;hs3:156286767-156287067,hs7:116119258-116119558;hs3:127951124-127951424,hs7:150837060-150837360;hs8:15525786-15526086,hs9:21422589-21422889;hs3:120930878-120931178,hs8:6347796-6348096;hs7:122408422-122408722,hs9:7744692-7744992;hs4:147347813-147348113,hs9:11837349-11837649;hs3:152844675-152844975,hs7:122408596-122408896;hs3:146637952-146638252,hs9:2207720-2208020;hs3:104155150-104155450,hs7:115370000-115370300;hs3:128284411-128284411,hs3:180373930-180373930;hs7:119836543-119836543,hs9:25500198-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Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	DPP6,TUSC3;KCND2,MLLT3;MDFIC,MCPH1;MME,MET;RHEB,PRKAG2;TMCC1,CLU
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	1,3,8,14	Chordoma	Next Generation Sequencing	Homo sapiens	PD3807a	Illumina Genome Analyzer II		hs1:26979575-26979875,hs8:69957063-69957363;hs1:30245671-30245671,hs1:38399550-38399550;hs1:31899334-31899334,hs3:150466521-150466521;hs1:31940315-31940315,hs8:919665-919665;hs1:32720036-32720036,hs8:69724087-69724087;hs1:34451346-34451346,hs3:152144281-152144281;hs1:39264122-39264122,hs8:69723165-69723165;hs1:50992002-50992002,hs8:55720159-55720159;hs1:70901720-70902020,hs8:50147581-50147881;hs1:71137728-71137728,hs5:139904720-139904720;hs3:2601916-2601916,hs14:76184263-76184263;hs3:2610083-2610083,hs5:140127749-140127749;hs3:3416718-3416718,hs14:67892033-67892033;hs3:11255004-11255004,hs3:20403223-20403223;hs3:16643353-16643353,hs14:104931398-104931398;hs3:20085341-20085341,hs3:157751761-157751761;hs3:32621814-32621814,hs3:151850188-151850188;hs3:53410516-53410516,hs3:146734291-146734291;hs3:57325976-57325976,hs14:76400221-76400221;hs3:58931785-58931785,hs8:69681901-69681901;hs3:58938129-58938129,hs3:60835256-60835256;hs3:64565291-64565291,hs8:57311429-57311429;hs3:129929497-129929797,hs14:94268591-94268891;hs3:130245385-130245385,hs14:68408332-68408332;hs3:136003981-136003981,hs8:87003917-87003917;hs3:136449926-136449926,hs3:158026243-158026243;hs3:141305365-141305365,hs3:141412115-141412115;hs3:146735572-146735572,hs8:56175908-56175908;hs3:146736430-146736430,hs14:75887005-75887005;hs3:161812795-161812795,hs5:139768903-139768903;hs5:109933566-109933566,hs5:119200299-119200299;hs8:50147822-50147822,hs14:94729283-94729283;hs8:50489945-50489945,hs8:87018123-87018123;hs8:55439756-55439756,hs14:102320080-102320080;hs8:55723885-55723885,hs8:87283463-87283463;hs8:67128213-67128213,hs14:94141759-94141759;hs8:69722663-69722963,hs14:75864127-75864427;hs8:69945067-69945067,hs14:67894685-67894685;hs14:68271232-68271232,hs14:93541559-93541559;hs16:68497215-68497215,hs16:73317076-73317076;hs3:140998678-140998978,hs8:56176216-56176516;hs1:70998381-70998681,hs14:104931320-104931620;hs1:32719745-32720045,hs3:161742587-161742887	ARID1A	Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	NA
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	8	Small cell lung cancer	Next Generation Sequencing	Homo sapiens	SCLC-21H	Illumina Genome Analyzer II		hs8:11334999-11334999,hs8:66529146-66529146;hs8:127488904-127489204,hs8:128760986-128761286;hs8:90066845-90066845,hs8:128859930-128859930;hs8:11330938-11331238,hs8:116315947-116316247;hs8:29625873-29625873,hs8:127545025-127545025;hs8:40494959-40495259,hs8:63578821-63579121;hs8:84078541-84078541,hs8:128774769-128774769;hs1:1104523-1104523,hs8:11303277-11303277;hs8:66433321-66433321,hs8:99226664-99226664;hs8:41381707-41381707,hs8:55578459-55578459;hs8:63584884-63584884,hs8:128840413-128840413;hs8:84096378-84096678,hs8:99276752-99277052;hs8:40540106-40540106,hs8:41382086-41382086;hs8:40339604-40339604,hs8:63659251-63659251;hs1:13658511-13658511,hs8:99232476-99232476;hs8:84104510-84104510,hs8:99330308-99330308;hs8:89927992-89927992,hs8:116377775-116377775;hs8:90028640-90028640,hs8:128761665-128761665;hs8:63602392-63602692,hs8:84121444-84121744;hs8:55612264-55612264,hs8:63246121-63246121;hs8:66498393-66498393,hs8:99256919-99256919;hs8:66447224-66447224,hs8:127528434-127528434;hs8:40355992-40355992,hs8:66481086-66481086;hs8:11269759-11269759,hs8:89936178-89936178;hs8:89956203-89956203,hs8:128765822-128765822;hs8:10621584-10621884,hs8:49802227-49802527;hs8:99273289-99273289,hs8:99280579-99280579;hs8:89954833-89954833,hs8:116356805-116356805;hs8:76384607-76384907,hs8:134647332-134647632;hs8:1003824-1003824,hs8:141999833-141999833;hs8:99318074-99318074,hs8:116325324-116325324;hs8:29641114-29641414,hs8:90005403-90005703;hs8:91926266-91926266,hs8:135534499-135534499;hs8:11252027-11252027,hs8:112539264-112539264;hs8:11239955-11239955,hs8:136340239-136340239;hs8:121837279-121837279,hs8:123774622-123774622;hs8:6667546-6667546,hs8:140843361-140843361;hs8:53604722-53605022,hs8:119331475-119331775;hs8:12622845-12623145,hs8:37781847-37782147;hs8:69085526-69085526,hs8:72157502-72157502;hs8:5921124-5921124,hs8:37922786-37922786;hs8:63424515-63424515,hs8:128768887-128768887;hs8:66451200-66451200,hs8:89934797-89934797;hs8:73092898-73092898,hs8:75122245-75122245;hs8:5923169-5923169,hs8:37103136-37103136;hs8:42555739-42556039,hs8:53416356-53416656;hs8:40344813-40344813,hs8:63613246-63613246;hs8:135261511-135261511,hs8:135459132-135459132;hs8:11318167-11318167,hs8:11325275-11325275;hs8:137408686-137408986,hs8:138979784-138980084;hs8:81970352-81970352,hs8:133921212-133921212;hs8:5577388-5577388,hs8:103976608-103976608;hs8:10869550-10869850,hs8:137489525-137489825;hs8:22454965-22454965,hs8:133758654-133758654;hs8:30198404-30198404,hs8:87186559-87186559;hs8:81490029-81490329,hs8:82207940-82208240;hs8:101805541-101805541,hs8:137328228-137328228;hs8:87195716-87196016,hs8:124310623-124310923;hs8:20165449-20165449,hs8:137411964-137411964;hs8:20715579-20715579,hs8:63840620-63840620;hs8:19455939-19456239,hs8:139725272-139725572;hs8:1885157-1885157,hs8:110183787-110183787;hs8:6439903-6439903,hs8:30899422-30899422;hs8:41698217-41698517,hs8:49711469-49711769;hs8:41531133-41531133,hs8:119159124-119159124;hs1:13722829-13722829,hs8:3402262-3402262;hs8:16740459-16740759,hs8:42436126-42436426;hs8:48923911-48923911,hs8:122969508-122969508;hs8:57061907-57061907,hs8:129237641-129237641;hs8:58330935-58330935,hs8:82283446-82283446;hs8:6436982-6436982,hs8:41378046-41378046;hs8:41378099-41378099,hs8:108886771-108886771;hs8:53082840-53082840,hs8:78461441-78461441;hs8:116275853-116275853,hs8:128828742-128828742;hs8:15704777-15704777,hs8:134608299-134608299;hs8:63090960-63090960,hs8:135329445-135329445;hs8:13586559-13586559,hs8:41787159-41787159;hs8:54855118-54855118,hs8:99974406-99974406;hs8:123883526-123883826,hs8:140842856-140843156;hs8:82709329-82709329,hs8:97955601-97955601;hs8:72083508-72083508,hs8:85848430-85848430;hs8:34648964-34648964,hs8:48847974-48847974;hs8:36361896-36361896,hs8:138502485-138502485;hs8:66479937-66480237,hs8:128825952-128826252;hs8:5176476-5176776,hs8:10727886-10728186;hs8:35832972-35832972,hs8:91411528-91411528;hs8:4370669-4370669,hs8:13784748-13784748;hs8:93723994-93723994,hs8:128402490-128402490;hs8:56516542-56516842,hs8:136073825-136074125;hs8:41455693-41455693,hs8:100196980-100196980;hs8:10648768-10649068,hs8:10712705-10713005;hs8:92636326-92636326,hs8:138924823-138924823;hs8:114147202-114147202,hs8:137491376-137491376;hs8:78324898-78324898,hs8:109073814-109073814;hs8:73877924-73877924,hs8:91348505-91348505;hs8:91348628-91348628,hs8:74002719-74002719;hs8:68133797-68133797,hs8:109759771-109759771;hs8:53708080-53708080,hs8:56789717-56789717;hs8:33447354-33447654,hs8:102357702-102358002;hs8:33646395-33646395,hs8:123077634-123077634;hs8:66629238-66629238,hs8:97684801-97684801;hs8:66438322-66438322,hs8:66509837-66509837;hs8:116188868-116188868,hs8:116193675-116193675;hs8:20312061-20312061,hs8:23887740-23887740;hs8:42495902-42495902,hs8:52109083-52109083;hs8:11329042-11329342,hs8:90066559-90066859;hs8:3354213-3354213,hs8:114008570-114008570;hs8:104149665-104149665,hs8:131922039-131922039;hs8:65277352-65277352,hs8:66084082-66084082;hs8:66084167-66084167,hs8:95888502-95888502;hs8:16829036-16829336,hs8:135763578-135763878;hs8:2015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Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	GINS4,EXT1
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	15	Colorectal cancer	Next Generation Sequencing	Homo sapiens	SNU-C1	Illumina Genome Analyzer 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Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	AVEN,PML;RORA,USP3;RYR3,PML;RYR3,TRIM69;SNURF,MTMR15;TCF12,CHD2;TCF12,Q6UXQ8_HUMAN
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	9	Thyroid cancer	Next Generation Sequencing	Homo sapiens	8505C	Illumina Genome Analyzer II		hs9:7454833-7454833,hs9:23145010-23145010;hs9:33098663-33098663,hs9:33789560-33789560;hs9:1579757-1580057,hs9:4663106-4663406;hs9:8949468-8949768,hs9:15540871-15541171;hs9:228188-228188,hs9:20424814-20424814;hs9:12762732-12762732,hs9:25879584-25879584;hs9:28587314-28587314,hs9:28670841-28670841;hs9:24506875-24506875,hs9:25193632-25193632;hs9:2952298-2952298,hs9:10667039-10667039;hs9:20852311-20852311,hs9:29560127-29560127;hs9:17454719-17454719,hs9:26368791-26368791;hs9:29419040-29419340,hs9:29660189-29660489;hs9:21777176-21777176,hs9:29568922-29568922;hs9:13145539-13145539,hs9:14221818-14221818;hs9:7980862-7980862,hs9:9928692-9928692;hs9:21948858-21948858,hs9:33397652-33397652;hs9:20453319-20453319,hs9:27238725-27238725;hs9:5100371-5100371,hs9:29054311-29054311;hs9:5889794-5889794,hs9:26668518-26668518;hs9:4422090-4422090,hs9:5116722-5116722;hs9:2290544-2290544,hs9:4605611-4605611;hs9:7247919-7247919,hs9:9929564-9929564;hs9:13512666-13512666,hs9:27132324-27132324;hs9:25058453-25058753,hs9:26498004-26498304;hs9:6019406-6019706,hs9:28380386-28380686;hs9:10765455-10765455,hs9:13039192-13039192;hs9:5011921-5011921,hs9:7764091-7764091;hs9:15143749-15143749,hs9:28595214-28595214;hs9:4651767-4651767,hs9:20901921-20901921;hs9:12737450-12737450,hs9:13124848-13124848;hs9:9373024-9373024,hs9:10071146-10071146;hs9:2506342-2506342,hs9:2644653-2644653;hs9:17724585-17724585,hs9:24527845-24527845;hs9:16442087-16442087,hs9:26864075-26864075;hs9:6089120-6089120,hs9:14603695-14603695;hs9:19499041-19499041,hs9:20013757-20013757;hs9:5055620-5055620,hs9:6317157-6317157;hs9:2859316-2859316,hs9:8867751-8867751;hs9:4591795-4591795,hs9:27240863-27240863;hs9:2138307-2138307,hs9:2719580-2719580;hs9:2852906-2852906,hs9:19629264-19629264;hs9:14293226-14293226,hs9:14513741-14513741;hs9:14322415-14322415,hs9:23245395-23245395;hs9:7955237-7955237,hs9:24407743-24407743;hs9:10323697-10323697,hs9:14426915-14426915;hs9:3262095-3262095,hs9:27825635-27825635;hs9:9415390-9415390,hs9:10722575-10722575;hs9:6366290-6366290,hs9:10018277-10018277;hs9:29619486-29619486,hs9:29691381-29691381;hs9:402038-402038,hs9:7374557-7374557;hs9:11704731-11704731,hs9:14050724-14050724;hs9:10359747-10359747,hs9:12587433-12587433;hs9:16395062-16395062,hs9:25840571-25840571;hs9:17644515-17644515,hs9:19650991-19650991;hs9:21724873-21724873,hs9:27350365-27350365;hs9:10626472-10626472,hs9:21786655-21786655;hs9:22382260-22382260,hs9:27758579-27758579;hs9:5288498-5288498,hs9:21459325-21459325;hs9:12418901-12418901,hs9:13734730-13734730;hs9:19502794-19503094,hs9:20827418-20827718;hs9:3104534-3104534,hs9:24190526-24190526;hs9:8934538-8934538,hs9:15718673-15718673;hs9:4507322-4507322,hs9:6998862-6998862;hs9:8588558-8588558,hs9:10067086-10067086;hs9:4716993-4716993,hs9:27515861-27515861;hs9:21912699-21912699,hs9:23468883-23468883;hs9:5080122-5080122,hs9:28373207-28373207;hs9:28470952-28470952,hs9:29452159-29452159;hs9:10747464-10747464,hs9:15140890-15140890;hs9:2773503-2773503,hs9:2826002-2826002;hs9:5020641-5020641,hs9:22930579-22930579;hs9:21029705-21029705,hs9:30556083-30556083;hs9:12665566-12665566,hs9:13117644-13117644;hs9:17654237-17654237,hs9:19771070-19771070;hs9:10321434-10321434,hs9:29595452-29595452;hs9:19104394-19104394,hs9:27734756-27734756;hs9:26413453-26413453,hs9:26756213-26756213	C9orf68;CDKN2A;JAK2;JMJD2C;KCNV2;KIAA1797;MLLT3;MPDZ;NFIB;SLC1A1;SMARCA2;TPD52L3	Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	C9orf68,KIAA1797;JAK2,TPD52L3;MPDZ,NFIB;SLC1A1,JMJD2C;SMARCA2,KCNV2
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	1	Synovial sarcoma	Next Generation Sequencing	Homo sapiens	SW982	Illumina Genome Analyzer II				Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	NA
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	11	Melanoma	Next Generation Sequencing	Homo sapiens	SC32	Illumina Genome Analyzer II				Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	NA
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	16	Glioblastoma	Next Generation Sequencing	Homo sapiens	A172	Illumina Genome Analyzer II				Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	NA
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	1,4,10,14	Pancreatic cancer	Next Generation Sequencing	Homo sapiens	PD3646a	Illumina Genome Analyzer II				Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	NA
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	12,20	Osteosarcoma	Next Generation Sequencing	Homo sapiens	PD3799a	Illumina Genome Analyzer II		hs12:58442187-58442187,hs12:57620230-57620230;hs12:57620497-57620497,hs12:58957976-58957976;hs20:7501303-7501303,hs20:43336042-43336042;hs12:57011311-57011311,hs12:57554249-57554249;hs12:67076643-67076943,hs12:67078090-67078390;hs20:2773550-2773550,hs20:23029205-23029205;hs20:17367251-17367251,hs20:21747854-21747854;hs12:64896001-64896001,hs12:67076811-67076811;hs12:66879952-66879952,hs12:73819282-73819282;hs12:59641861-59641861,hs12:59342711-59342711;hs12:59342779-59342779,hs12:68303999-68303999;hs12:37900026-37900026,hs12:57263787-57263787;hs12:38289239-38289239,hs12:38309029-38309029;hs20:25223958-25224258,hs20:52966624-52966924;hs20:52039440-52039440,hs20:60256737-60256737;hs12:65629910-65629910,hs12:66479252-66479252;hs12:66316446-66316446,hs12:74211707-74211707;hs12:67671294-67671294,hs12:69870130-69870130;hs20:21439646-21439946,hs20:22033696-22033996;hs20:17412002-17412002,hs20:50802396-50802396;hs12:58428539-58428839,hs12:66811518-66811818;hs12:65789899-65789899,hs12:73627618-73627618;hs12:58912619-58912619,hs12:66695126-66695126;hs12:56074829-56074829,hs12:66023883-66023883;hs12:57025231-57025231,hs12:70247750-70247750;hs12:55988628-55988628,hs12:58481314-58481314;hs12:57290916-57290916,hs12:69220231-69220231;hs12:68246320-68246320,hs12:65313009-65313009;hs12:65312973-65312973,hs12:68247450-68247450;hs20:34354393-34354393,hs20:43844955-43844955;hs12:66649897-66649897,hs12:70220390-70220390;hs12:39452938-39452938,hs12:67694878-67694878;hs12:55957687-55957687,hs12:67026716-67026716;hs12:65570296-65570296,hs12:67574938-67574938;hs20:59727255-59727255,hs20:59880825-59880825;hs20:47000736-47000736,hs20:55792873-55792873;hs12:39454856-39454856,hs12:56573381-56573381;hs20:7141982-7141982,hs20:31100556-31100556;hs12:60388899-60388899,hs12:66908919-66908919;hs12:65253483-65253483,hs12:67018446-67018446;hs12:69881026-69881026,hs12:70299595-70299595;hs12:64506231-64506531,hs12:70132255-70132555;hs12:64502447-64502747,hs12:67215504-67215804;hs12:37173408-37173408,hs12:57397386-57397386;hs12:57779502-57779502,hs12:73945700-73945700;hs12:37593874-37593874,hs12:58987651-58987651;hs12:59292511-59292511,hs12:67150585-67150585;hs12:60428880-60429180,hs12:69403640-69403940;hs12:67470416-67470716,hs12:67471539-67471839;hs12:60123239-60123239,hs12:66815116-66815116;hs20:23295971-23295971,hs20:43085308-43085308;hs12:40208112-40208112,hs12:55974495-55974495;hs12:39976799-39976799,hs12:65238670-65238670;hs20:20615726-20615726,hs20:38766439-38766439;hs12:66356997-66356997,hs12:67797477-67797477;hs12:39826082-39826082,hs12:65283127-65283127;hs12:66695545-66695545,hs12:67857536-67857536;hs12:59846330-59846330,hs12:68244402-68244402;hs12:40350865-40350865,hs12:66125080-66125080;hs12:56572643-56572643,hs12:57290007-57290007;hs12:40343752-40343752,hs12:66003117-66003117;hs12:40004615-40004615,hs12:73459440-73459440;hs12:56316123-56316123,hs12:59359795-59359795;hs12:57829380-57829380,hs12:66032035-66032035;hs12:67013937-67013937,hs12:73509415-73509415;hs12:56835299-56835299,hs12:58031479-58031479;hs12:57025146-57025446,hs12:70247553-70247853;hs20:48658235-48658235,hs20:59724130-59724130;hs12:66553441-66553441,hs12:69990363-69990363;hs20:34354352-34354652,hs20:43844786-43845086;hs12:40417611-40417611,hs12:68190511-68190511;hs12:37614161-37614161,hs12:65369721-65369721;hs12:64502447-64502747,hs12:67215504-67215804;hs12:75195155-75195155,hs12:75196750-75196750;hs12:57763521-57763521,hs12:68088382-68088382;hs20:44155408-44155408,hs20:46026329-46026329;hs12:66325398-66325398,hs12:67282959-67282959;hs12:66297342-66297342,hs12:68775855-68775855;hs20:17758396-17758396,hs20:61252776-61252776;hs12:37593936-37594236,hs12:58987599-58987899;hs12:38720447-38720447,hs12:67489340-67489340;hs12:57620431-57620431,hs12:58486346-58486346;hs12:57997044-57997044,hs12:67474026-67474026;hs20:52163530-52163530,hs20:53475058-53475058;hs20:12865832-12865832,hs20:52036066-52036066;hs12:38142661-38142661,hs12:38821302-38821302;hs12:57400320-57400320,hs12:74122877-74122877;hs20:2773142-2773442,hs20:23028901-23029201;hs12:65412680-65412680,hs12:67660836-67660836;hs20:17367052-17367352,hs20:21747809-21748109;hs12:60009145-60009145,hs12:66006029-66006029;hs12:64895742-64896042,hs12:67076821-67077121;hs12:57304371-57304371,hs12:65919665-65919665;hs12:39870405-39870405,hs12:74420235-74420235;hs12:55988642-55988642,hs12:58481060-58481360;hs12:56233854-56233854,hs12:68211530-68211530;hs20:59727302-59727602,hs20:59880557-59880857;hs20:7141866-7142166,hs20:31100419-31100719;hs12:64506231-64506531,hs12:70132255-70132555;hs12:59002439-59002439,hs12:69951395-69951395;hs20:38833017-38833017,hs20:45835704-45835704;hs12:56777639-56777639,hs12:57102652-57102652;hs12:37613230-37613230,hs12:70256621-70256621;hs12:70497500-70497500,hs12:73380213-73380213;hs12:67327766-67327766,hs12:73440723-73440723	GZF1;STK4	Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	GZF1,STK4
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	8,12,14	Osteosarcoma	Next Generation Sequencing	Homo sapiens	PD3786a	Illumina Genome Analyzer II		hs3:118093916-118093916,hs3:118426816-118426816;hs4:177436270-177436270,hs22:32553886-32553886;hs5:14715569-14715569,hs17:31949191-31949191;hs7:69644187-69644187,hs7:69876978-69876978;hs8:3168052-3168052,hs8:3939631-3939631;hs8:3583877-3583877,hs14:50924581-50924581;hs8:3603627-3603627,hs14:36679515-36679515;hs8:3685593-3685593,hs14:34524805-34524805;hs8:4167645-4167645,hs14:33699490-33699490;hs8:5868740-5868740,hs14:52866436-52866436;hs8:6133331-6133331,hs8:6251428-6251428;hs8:6135587-6135587,hs14:52515435-52515435;hs8:6494155-6494155,hs8:6515408-6515408;hs8:8909506-8909506,hs8:21278604-21278604;hs8:9789525-9789525,hs8:11858135-11858135;hs8:9817353-9817353,hs8:11469184-11469184;hs8:9834568-9834568,hs8:17016047-17016047;hs8:10383750-10383750,hs8:14278669-14278669;hs8:10388325-10388325,hs8:10493176-10493176;hs8:10416024-10416024,hs8:11104659-11104659;hs8:10422441-10422441,hs8:17483930-17483930;hs8:10626797-10626797,hs8:21210586-21210586;hs8:10920388-10920388,hs8:16882348-16882348;hs8:10925607-10925607,hs8:17536211-17536211;hs8:11115284-11115284,hs8:13237022-13237022;hs8:11342940-11342940,hs8:17601844-17601844;hs8:11625722-11625722,hs8:11862030-11862030;hs8:11627133-11627133,hs14:37796212-37796212;hs8:12460390-12460390,hs8:21613065-21613065;hs8:13207928-13207928,hs8:21227969-21227969;hs8:13210727-13210727,hs8:13275530-13275530;hs8:13268473-13268473,hs8:17496360-17496360;hs8:16875456-16875456,hs8:21215670-21215670;hs8:20331966-20331966,hs8:20393586-20393586;hs8:21302938-21302938,hs14:26558249-26558249;hs8:91341238-91341238,hs8:141775822-141775822;hs8:141571747-141571747,hs12:16046949-16046949;hs8:142747126-142747126,hs12:16430865-16430865;hs8:142747678-142747678,hs12:16603247-16603247;hs8:142845370-142845370,hs8:143474860-143474860;hs8:144181010-144181010,hs12:3880124-3880124;hs9:129999857-129999857,hs9:130014062-130014062;hs10:112373403-112373403,hs19:17271609-17271609;hs10:112373452-112373452,hs22:34941910-34941910;hs12:1815281-1815281,hs12:12569624-12569624;hs12:4316907-4316907,hs14:102135076-102135076;hs12:8757731-8757731,hs12:8847883-8847883;hs12:9411021-9411021,hs14:27661974-27661974;hs12:10980072-10980072,hs12:30029899-30029899;hs12:11027103-11027103,hs14:102139231-102139231;hs12:11366981-11366981,hs14:94525195-94525195;hs12:12573054-12573054,hs12:30002256-30002256;hs12:12586928-12586928,hs14:102111610-102111610;hs12:12597865-12597865,hs14:99429192-99429192;hs12:12687540-12687540,hs12:14245323-14245323;hs12:14117741-14117741,hs12:14185562-14185562;hs12:16049923-16049923,hs12:17462418-17462418;hs12:16051037-16051037,hs12:23459482-23459482;hs12:16051062-16051062,hs12:17462804-17462804;hs12:16054806-16054806,hs12:16463017-16463017;hs12:16433142-16433142,hs12:16466398-16466398;hs12:16436484-16436484,hs12:23822360-23822360;hs12:20337069-20337069,hs16:9621049-9621049;hs12:29963884-29963884,hs14:96813809-96813809;hs12:30014548-30014548,hs14:99450969-99450969;hs12:69443870-69443870,hs12:94616586-94616586;hs12:69528086-69528086,hs12:96433506-96433506;hs12:95629192-95629192,hs12:96135863-96135863;hs12:95909413-95909413,hs12:96157768-96157768;hs14:26550303-26550303,hs14:26587979-26587979;hs14:27664758-27664758,hs14:54170365-54170365;hs14:27671101-27671101,hs14:37793569-37793569;hs14:28723349-28723349,hs14:28745622-28745622;hs14:28743412-28743412,hs14:36721446-36721446;hs14:28753669-28753669,hs14:47494643-47494643;hs14:28767333-28767333,hs14:47493254-47493254;hs14:28957683-28957683,hs14:43733199-43733199;hs14:33697734-33697734,hs14:33700245-33700245;hs14:34525615-34525615,hs14:50800669-50800669;hs14:36632961-36632961,hs14:49464699-49464699;hs14:36752027-36752027,hs14:42844674-42844674;hs14:40070726-40070726,hs14:50931706-50931706;hs14:48806826-48806826,hs14:50956419-50956419;hs14:50974535-50974535,hs14:93501647-93501647;hs14:51140501-51140501,hs14:52932863-52932863;hs14:51343897-51343897,hs14:90906379-90906379;hs14:53076409-53076409,hs14:90957960-90957960;hs14:90870347-90870347,hs14:90957576-90957576;hs14:90906448-90906448,hs14:90906383-90906383;hs14:96798857-96798857,hs14:102080242-102080242;hs16:5520573-5520573,hs16:6093705-6093705;hs16:6184030-6184030,hs16:6185476-6185476;hs16:6244340-6244340,hs16:20556910-20556910;hs16:7089113-7089113,hs16:7739957-7739957;hs16:7906912-7906912,hs16:32551273-32551273;hs16:20340850-20340850,hs16:25864734-25864734;hs17:3356980-3356980,hs17:19605371-19605371;hs17:4646185-4646185,hs17:15822489-15822489;hs17:15819233-15819233,hs17:19182180-19182180;hs17:17634699-17634699,hs20:44505837-44505837;hs17:19604264-19604264,hs20:44548966-44548966;hs17:41558942-41558942,hs22:34941922-34941922;hs18:10824696-10824696,hs18:51654932-51654932;hs18:10824697-10824697,hs18:10824728-10824728;hs18:35339189-35339189,hs18:35392785-35392785;hs18:49622225-49622225,hs20:32287220-32287220;hs18:64755617-64755617,hs18:65131219-65131219;hs20:29299369-29299369,hs20:32231405-32231405;hs20:44418631-44418631,hs20:44545380-44545380;hs22:32554028-32554028,hs4:177585285-177585285;hsY:8187550-8187550,hsY:8189429-8189429;hs12:4357009-4357009,hs12:10955611-10955611;hs8:10630023-10630323,hs8:11595592-11595892;hs8:9790035-9790335,hs8:21229839-21230139;hs14:33108356-33108656,hs14:34528126-34528426;hs12:29986214-29986214,hs14:102097072-102097072;hs12:90631856-90632156,hs12:94612735-94613035	Q6ZP57_HUMAN;GFRA2	Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	Q6ZP57_HUMAN,GFRA2
Research	21215367	Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal S, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Quail MA, Burton J, Swerdlow H, Carter NP, M	Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development	Cell	2011 Jan	7,9,12,13	Osteosarcoma	Next Generation Sequencing	Homo sapiens	PD3791a	Illumina Genome Analyzer II		hs13:59499579-59499579,hs13:82915974-82915974;hs21:30622804-30622804,hs21:30634524-30634524;hs13:77097904-77097904,hs13:94876739-94876739;hs8:135611010-135611010,hs8:135762196-135762196;hs7:17553972-17553972,hs7:35734706-35734706;hs13:60955586-60955586,hs13:82714826-82714826;hs13:48205283-48205283,hs13:50150066-50150066;hs7:69785170-69785170,hs7:69874968-69874968;hs5:176893660-176893660,hs5:176952466-176952466;hs7:15578703-15578703,hs7:34543166-34543166;hs13:78597797-78597797,hs13:79236995-79236995;hs13:82714808-82714808,hs13:84088098-84088098;hs7:15570337-15570337,hs9:131506924-131506924;hs7:33158940-33158940,hs13:100442204-100442204;hs9:131022073-131022073,hs12:12982393-12982393;hs7:15568375-15568375,hs13:48072900-48072900;hs7:17553579-17553579,hs13:81855713-81855713;hs7:34373151-34373151,hs13:82810817-82810817;hs9:130352994-130352994,hs12:11686468-11686468;hs7:15578929-15578929,hs13:107501387-107501387;hs7:35987789-35987789,hs13:56881282-56881282;hs7:34005998-34005998,hs13:48900633-48900633;hs7:34317837-34317837,hs13:49109337-49109337;hs9:130949365-130949365,hs13:84216848-84216848;hs9:131526566-131526566,hs13:48780919-48780919;hs17:7835375-7835375,hs17:7848044-7848044;hs8:48530501-48530501,hs8:70657533-70657533;hs13:60925213-60925213,hs13:82968411-82968411;hs13:84755845-84755845,hs13:92223455-92223455;hs13:43974978-43974978,hs13:82820285-82820285;hs4:11022842-11022842,hs4:11336969-11336969;hs8:86571587-86571587,hs8:97625240-97625240;hs13:102720277-102720277,hs13:103442443-103442443;hs13:81765610-81765610,hs13:85422486-85422486;hs13:87073096-87073096,hs13:87597947-87597947;hs8:84069743-84069743,hs8:103185573-103185573;hs13:31438240-31438240,hs13:49129602-49129602;hs13:49121696-49121696,hs13:56881285-56881285;hs8:80283311-80283311,hs8:119951058-119951058;hs13:78986804-78986804,hs13:92854589-92854589;hs13:84223964-84223964,hs13:89446785-89446785;hs7:15392876-15392876,hs7:16002674-16002674;hs13:83182133-83182133,hs13:84909048-84909048;hs13:84211057-84211057,hs13:92634637-92634637;hs10:15522819-15522819,hs10:15581536-15581536;hs17:7816821-7816821,hs17:7871527-7871527;hs8:68122659-68122659,hs8:92203315-92203315;hs2:5785041-5785341,hs2:5864425-5864725;hs5:14646093-14646393,hs5:14855324-14855624;hs6:71196895-71196895,hs6:71233346-71233346;hs7:17128705-17129005,hs13:101720860-101721160;hs7:17545091-17545091,hs9:130959968-130959968;hs7:17561816-17562116,hs13:49038306-49038606;hs7:17715498-17715498,hs7:34743376-34743376;hs7:33166625-33166625,hs13:84769984-84769984;hs7:34318132-34318132,hs13:84082986-84082986;hs7:34435925-34435925,hs7:35821800-35821800;hs7:34445925-34445925,hs13:94901467-94901467;hs7:34751314-34751614,hs13:83387061-83387361;hs7:35452585-35452585,hs13:48086547-48086547;hs7:35461291-35461291,hs13:83511816-83511816;hs7:35821965-35821965,hs13:50109227-50109227;hs7:36323243-36323243,hs13:49415266-49415266;hs7:36325447-36325447,hs13:95750937-95750937;hs8:10319985-10319985,hs8:72336297-72336297;hs8:10627693-10627693,hs8:19900359-19900359;hs8:15264001-15264001,hs8:48514905-48514905;hs8:17254278-17254278,hs8:84925287-84925287;hs8:19935905-19935905,hs8:105748022-105748022;hs8:21975069-21975069,hs8:84528700-84528700;hs8:49662696-49662696,hs8:125935980-125935980;hs8:89617303-89617303,hs8:95342668-95342668;hs8:93948443-93948443,hs8:102986476-102986476;hs8:131065144-131065144,hs8:131216815-131216815;hs9:130948824-130948824,hs13:48089482-48089482;hs10:80680600-80680600,hs10:80806585-80806585;hs11:85062165-85062165,hs11:85134471-85134471;hs11:69623478-69623778,hs11:69805619-69805919;hs12:11668570-11668570,hs13:92225461-92225461;hs13:31438241-31438241,hs13:49121691-49121691;hs13:41774644-41774644,hs13:85405618-85405618;hs13:43965419-43965419,hs13:52397246-52397246;hs13:43974532-43974532,hs13:49312362-49312362;hs13:44454294-44454294,hs13:48921870-48921870;hs13:47966014-47966014,hs13:95733556-95733556;hs13:48093779-48093779,hs13:94426410-94426410;hs13:48780835-48781135,hs13:80597813-80598113;hs13:48900350-48900350,hs13:82993208-82993208;hs13:48982947-48982947,hs13:107521925-107521925;hs13:49000163-49000163,hs13:81941909-81941909;hs13:49067280-49067280,hs13:56844933-56844933;hs13:49129599-49129599,hs13:78642773-78642773;hs13:49420650-49420650,hs13:56903507-56903507;hs13:50149573-50149573,hs13:92024874-92024874;hs13:92024822-92024822,hs13:92024888-92024888;hs13:50554976-50554976,hs13:89486704-89486704;hs13:60895207-60895207,hs13:84029239-84029239;hs13:65952585-65952585,hs13:77959707-77959707;hs13:73123219-73123219,hs13:94769714-94769714;hs13:74562077-74562077,hs13:84886089-84886089;hs13:76772706-76772706,hs13:81872343-81872343;hs13:77076546-77076846,hs13:82934400-82934700;hs13:80570746-80570746,hs13:103342070-103342070;hs13:80600527-80600527,hs13:89064951-89064951;hs13:83830407-83830407,hs13:84046864-84046864;hs13:84046794-84046794,hs13:84881848-84881848;hs13:84773871-84773871,hs13:94876655-94876655;hs13:86636203-86636203,hs13:94901020-94901020;hs13:89050628-89050628,hs13:90372387-90372387;hs13:92186056-92186056,hs13:92272100-92272100;hs13:49020561-49020861,hs13:94460207-94460507;hs13:61466108-61466408,hs13:89045402-89045702;hs7:34050050-34050350,hs7:35417964-35418264;hs13:50146435-50146735,hs13:59499522-59499822	SPTAN1;ETV6	Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK	Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby tens to hundreds of genomic rearrangements occur in a one-off cellular crisis. Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states. These genomic hallmarks are highly improbable if rearrangements accumulate over time and instead imply that nearly all occur during a single cellular catastrophe. The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ~25% of bone cancers. We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis. This phenomenon has important implications for the origins of genomic remodeling and temporal emergence of cancer.	NCBI 36/hg18				Yes	SPTAN1,ETV6